In silico screening of mint leaves compound (Mentha piperita L.) as a potential inhibitor of SARS-CoV-2


 Introduction: The novel coronavirus in Wuhan, China, was identified at the end of December 2019 and resulted a global outbreak. Therefore, it is necessary to perform screening compounds herbal plants with antiviral potential against COVID-19. Mint leaves (Mentha piperita L.) were reported as one proposed samples, this study performed silico evaluate activity content. Methods:The mechanism action includes inhibition SARS-CoV-2 proteins from binding receptor. Subsequently, several receptors associated validated, code PDB 5R7Y an RMSD value 1.9974 Ã… obtained using YASARA application. This on 15 virtual mint five previously studied comparison inhibitory capacity. docking started PLANTS application, results visualised PyMol further identify amino acids contained ligand, while statistical t-test used for comparison. Results: showed existence active leaves, including rutin, hesperidin, isorhoifolin.